Enantiospecific Two-Photon Electric-Dipole Selection Rule of Chiral Molecules

Abstract

Distinguishing between enantiomers is crucial in the study of chiral molecules in chemistry and pharmacology. Many optical approaches rely on enantiospecific cyclic electric-dipole transitions induced by three microwave or laser beams. However, these approaches impose stringent requirements, including phase locking, three-photon resonance, and precise control over beam intensities and operation times, which enhance the complexity and restrict the applicability. In this letter, we present a novel optical method that {\it eliminates these constraints entirely.} Specifically, we demonstrate that in the presence of a static electric field, there is a selection rule for two-photon electric-dipole transitions that differs between enantiomers. This distinction arises because the static electric field breaks the symmetry associated with the combined action of a specific rotation and time-reversal transformation. Leveraging the enantiospecific two-photon selection rule, one can selectively excite a desired enantiomer using two beams, without the need for phase locking, resonance condition, and the precise control of their intensities and operation times. Our method significantly enhances the feasibility and applicability of optical approaches for enantiomer differentiation.

arXiv comment13 pages, 5 figures

References in corpus (32)

• Sensitive Chiral Analysis via Microwave Three-wave Mixing
• Two-Step Enantio-selective Optical Switch
• Enantiomer-Specific State Transfer of Chiral Molecules
• Generalized Stern-Gerlach Effect for Chiral Molecules
• Optically-Induced Highly-Efficient Detection and Separation of Chiral Molecules through Shortcuts to Adiabaticity
• Probing weak force induced parity violation by high resolution mid-infrared molecular spectroscopy
• Principles of enantio-selective excitation in three-wave mixing spectroscopy of chiral molecules
• Dynamic method to distinguish between left- and right-handed chiral molecules
• Detecting chirality in molecules by linearly polarized laser fields
• Two-path interference for enantiomer-selective state transfer of chiral molecules
• A new chiral electro-optic effect: Sum-frequency generation from optically active liquids in the presence of a dc electric field
• Remark on laser linewidth hazard in opto-mechanical cooling
• Robust and highly-efficient discrimination of chiral molecules through three-mode parallel paths
• Influence Spatial Degeneracy on Rotational Spectroscopy Three Wave Mixing and enantiomeric state separation of Chiral Molecules
• Real single-loop cyclic three-level configuration of chiral molecules
• Effect of molecular rotation on enantioseparation
• Determination of enantiomeric excess with chirality-dependent AC Stark effects in cyclic three-level models
• Effective two-level models for highly efficient inner-state enantio-separation based on cyclic three-level systems of chiral molecules
• Complete Controllability Despite Degeneracy: Quantum Control of Enantiomer-Specific State Transfer in Chiral Molecules
• State-specific Enrichment of Chiral Conformers with Microwave Spectroscopy
• Chiral resolution by composite Raman pulses
• Efficient and robust chiral resolution by composite pulses
• Distinguishing left- and right-handed molecules by two-step coherent pulses
• Cyclic three-level-pulse-area theorem for enantioselective state transfer of chiral molecules
• Spatial enantioseparation of gaseous chiral molecules
• Enantio-detection of cyclic three-level chiral molecules in a driven cavity
• Entanglement-Assisted Quantum Chiral Spectroscopy
• Vacuum-Induced Symmetry Breaking of Chiral Enantiomer Formation in Chemical Reactions
• Single-shot Non-destructive Quantum Sensing for Gaseous Samples with Hundreds of Chiral Molecules
• Enantio-specific state transfer for symmetric-top chiral molecules
• Quantum control of ro-vibrational dynamics and application to light-induced molecular chirality
• Enantiomer-Specific Pumping of Chiral Molecules