Resonance-Driven Mechanisms of Ion Transport and Selectivity
arXiv:2503.02617 · doi:10.1103/PhysRevE.100.062410
Abstract
Ion channels selectively transport ions, yet the underlying mechanisms remain elusive. We propose a physical model based on the Driven Damped Harmonic Oscillator (DDHO), where self-organizing turbulent structures in the ionic flow generate oscillating pressure waves and toroidal vortices. These structures drive aqua-ions into resonance, facilitating the shedding of hydration shells and enabling ion permeation as free ions. To capture the spatiotemporal complexity of this process, we develop a macroscopic continuum model integrating the Navier--Stokes equations, Gauss's law, and convection-diffusion dynamics. Numerical simulations reveal strong oscillations that drive dehydration and ionic jet formation, supporting the DDHO mechanism. Model predictions closely match patch-clamp experimental data. The DDHO framework predicts a frequency-dependent resonance response, effectively acting as a selective filter. Applied to experimental data, the model reveals distinct separation between ion species and hydration states, quantified by a high Mahalanobis distance and oscillator quality factor. Furthermore, the model provides insight into the effects of single nucleotide polymorphisms (SNPs) on ion selectivity. Mutations that alter channel geometry shift resonance peaks, disrupting selective transport and potentially leading to genetic disorders.
arXiv commentExtended version based on Physical Review E, Volume 100, Issue 6, article id.062410. Dec 2019, 43 pages, 38 figures
References in corpus (12)
- Quasinormal modes of black holes: from astrophysics to string theory
- Dehydration as a Universal Mechanism for Ion Selectivity in Graphene and Other Atomically Thin Pores
- Rectification in synthetic conical nanopores: a one-dimensional Poisson-Nernst-Planck modeling
- Periodic orbits near onset of chaos in plane Couette flow
- The physical origin of hydrophobic effects
- Renormalization-group approach to the stochastic Navier--Stokes equation: Two-loop approximation
- Residence Time Statistics for Normal and Fractional Diffusion in a Force Field
- Ergodicity Breaking in a Deterministic Dynamical System
- Entropic forces in Brownian motion
- Periodic motion representing isotropic turbulence
- A Derivation of the Vlasov-Navier-Stokes Model for Aerosol Flows from Kinetic Theory
- Entropy facilitated active transport