Cells around the corner
arXiv:2501.07517 · doi:10.1039/D5SM00093A
Abstract
The study of spindle-like cells as nematic liquid crystals has led to remarkable insights in the understanding of tissue organization and morphogenesis. In the characterization of this anomalous liquid crystal material, we focus on the energetic cost of splay and bend deformations, in order to determine the elastic anisotropy of the material, i.e. the ratio of the elastic constants associated with splay and bend. We explore the behavior of monolayers of cells in proximity to corners, where cells arrange in splay or bend configuration, strongly dependent on the amplitude of the wedge angle. The angle at which splay and bend deformations are equally likely is determined by the ratio between splay and bend elastic constants. We also show that the splay and bend deformations under confinement can be well approximated using equilibrium liquid crystal theory and statistical mechanics. Finally, our data suggest that for fibroblast cells the common approximation of equal bend and splay constant is valid.
9 pages and 3 figures + 5 supplemental pages and 4 supplemental figures
References in corpus (17)
- The Mechanics and Statistics of Active Matter
- Topological defect launches 3D mound in the active nematic sheet of neural progenitors
- Topological active matter
- Orientational order of motile defects in active nematics
- Defect dynamics in active nematics
- Active wetting of epithelial tissues
- Topological defects promote layer formation in Myxococcus xanthus colonies
- Tunable structure and dynamics of active liquid crystals
- Defect-mediated morphologies in growing cell colonies
- Emergence of active nematic behaviour in monolayers of isotropic cells
- Excitable Patterns in Active Nematics
- Quantifying material properties of cell monolayers by analyzing integer topological defects
- Patterning of morphogenetic anisotropy fields
- Integer topological defects of cell monolayers -- mechanics and flows
- Chiral stresses in nematic cell monolayers
- Chirality, anisotropic viscosity and elastic anisotropy in three-dimensional active nematic turbulence
- Does nematic order allow groups of elongated cells to sense electric fields better?