Mechanics promotes coherence in heterogeneous active media

Abstract

Synchronization of activity among myocytes constituting vital organs, e.g., the heart, is crucial for physiological functions. Self-organized coordination in such heterogeneous ensemble of excitable and oscillatory cells is therefore of clinical importance. We show by varying the strength of intercellular coupling and the electrophysiological diversity, a wide range of collective behavior emerges including clusters of synchronized activity. Strikingly, stretch-activated currents allow waves of mechanical deformation to alter the activity of neighboring cells, promoting robust global coherence.

6 pages, 3 figures + 1 page Supplementary Information for 3 supplementary videos