A topological mechanism for robust and efficient global oscillations in biological networks

Abstract

Long and stable timescales are often observed in complex biochemical networks, such as in emergent oscillations. How these robust dynamics persist remains unclear, given the many stochastic reactions and shorter time scales demonstrated by underlying components. We propose a topological model that produces long oscillations around the network boundary, reducing the system dynamics to a lower-dimensional current in a robust manner. Using this to model KaiC, which regulates the circadian rhythm in cyanobacteria, we compare the coherence of oscillations to that in other KaiC models. Our topological model localizes currents on the system edge, with an efficient regime of simultaneously increased precision and decreased cost. Further, we introduce a new predictor of coherence from the analysis of spectral gaps, and show that our model saturates a global thermodynamic bound. Our work presents a new mechanism and parsimonious description for robust emergent oscillations in complex biological networks.

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Cited by in corpus (10)

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• Non-reciprocity is necessary for robust dimensional reduction and strong responses in stochastic topological systems
• Topological phases in discrete stochastic systems
• Topological edge flows drive macroscopic re-organization in magnetic colloids
• Thermodynamic Geometric Constraint on the Spectrum of Markov Rate Matrices
• $Q$-functions, synchronization, and Arnold tongues for coupled stochastic oscillators
• Designing topological cluster synchronization patterns with the Dirac operator
• Topology of the simplest gene switch
• Microcanonical ensemble out of equilibrium