Variational approximation method for the long-range force transmission in biopolymer gels

Abstract

The variational principle of minimum free energy (MFEVP) has been widely used in the study of soft matter statics. MFEVP can be used not only to derive equilibrium equations (including both bulk equations and boundary conditions), but also to develop direct variational methods (such as Ritz method) to find approximate solutions to these equilibrium equations. In this work, we applied these variational methods to study long-range force transmission in nonlinear elastic biopolymer gels. We showed that the slow decay of cell-induced displacements measured experimentally for fibroblast spheroids in three-dimensional fibrin gels can be well explained by variational approximations based on the three-chain model of biopolymer gels.

11 pages, 4 figures

References in corpus (5)

• Strain-induced alignment in collagen gels
• Long Range Force Transmission in Fibrous Matrices Enabled by Tension-Driven Alignment of Fibers
• Microbuckling of Fibrin Provides a Mechanism for Cell Mechanosensing
• Onsager's variational principle in active soft matter
• Continuum elastic models for force transmissions in biopolymer gels