Enantiodetection of chiral molecules via two-dimensional spectroscopy

Abstract

Enantiodetection of chiral molecules is important to pharmaceutical drug production, chemical reaction control, and biological function designs. Traditional optical methods of enantiodetection rely on the weak magnetic-dipole or electric-quadrupole interactions, and in turn suffer from the weak signal and low sensitivity. We propose a new optical enantiodetection method to determine the enantiomeric excess via two-dimensional (2D) spectroscopy of the chiral mixture driven by three electromagnetic fields. The quantities of left- and right- handed chiral molecules are reflected by the intensities of different peaks on the 2D spectrum, separated by the chirality-dependent frequency shifts resulting from the relative strong electric-dipole interactions between the chiral molecules and the driving fields. Thus, the enantiomeric excess can be determined via the intensity ratio of the peaks for the two enantiomers.

6 pages, 4 figures

References in corpus (9)

• Enantiomer-Specific State Transfer of Chiral Molecules
• Generalized Stern-Gerlach Effect for Chiral Molecules
• Chiral molecules split light: Reflection and refraction in a chiral liquid
• Optically-Induced Highly-Efficient Detection and Separation of Chiral Molecules through Shortcuts to Adiabaticity
• Principles of enantio-selective excitation in three-wave mixing spectroscopy of chiral molecules
• Dynamic method to distinguish between left- and right-handed chiral molecules
• Two-Dimensional Terahertz Spectroscopy of Condensed-Phase Molecular Systems
• Effect of molecular rotation on enantioseparation
• Entanglement-Assisted Quantum Chiral Spectroscopy

Cited by in corpus (3)

• Enantiodiscrimination of chiral molecules via quantum correlation function
• Phase-matched locally chiral light for global control of chiral light-matter interaction
• Optical-pumping enantio-conversion of chiral mixtures in presence of tunneling between chiral states