The impact of contact inhibition on collective cell migration and proliferation

Abstract

Contact inhibition limits migration and proliferation of cells in cell colonies. We consider a multiphase field model to investigate the growth dynamics of a cell colony, composed of proliferating cells. The model takes into account the mechanisms of contact inhibition of locomotion and proliferation by local mechanical interactions. We compare non-migrating and migrating cells, in order to provide a quantitative characterization of the dynamics and analyse the velocity of the colony boundary for both cases. Additionally, we measure single cell velocities, number of neighbour distributions, as well as the influence of stress and age on positions of the cells and with respect to each other. We further compare the findings with experimental data for Madin-Darby canine kidney cells

5 pages, 5 figures

References in corpus (4)

• Solid-Liquid Transition of Deformable and Overlapping Active Particles
• Non-equilibrium phase separation with reactions: A canonical model and its behaviour
• A mechanism for cell motility by active polar gels
• Multiphase field models for collective cell migration

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• Minimal cellular automaton model with heterogeneous cell sizes predicts epithelial colony growth
• Motion Ordering in Cellular Polar-polar and Polar-nonpolar Interactions