The impact of contact inhibition on collective cell migration and proliferation

Abstract

Contact inhibition limits migration and proliferation of cells in cell colonies. We consider a multiphase field model to investigate the growth dynamics of a cell colony, composed of proliferating cells. The model takes into account the mechanisms of contact inhibition of locomotion and proliferation by local mechanical interactions. We compare non-migrating and migrating cells, in order to provide a quantitative characterization of the dynamics and analyse the velocity of the colony boundary for both cases. Additionally, we measure single cell velocities, number of neighbour distributions, as well as the influence of stress and age on positions of the cells and with respect to each other. We further compare the findings with experimental data for Madin-Darby canine kidney cells

arXiv comment5 pages, 5 figures

References in corpus (15)

• Athermal Phase Separation of Self-Propelled Particles with no Alignment
• Growth and Division of Active Droplets: A Model for Protocells
• Collective and single cell behavior in epithelial contact inhibition
• Physical Models of Collective Cell Migration
• Cooperative Motion of Active Brownian Spheres in Three-Dimensional Dense Suspensions
• Reentrant Phase Behavior in Active Colloids with Attraction
• Emergence of active nematic behaviour in monolayers of isotropic cells
• Study on Multicellular Systems Using a Phase Field Model
• Solid-Liquid Transition of Deformable and Overlapping Active Particles
• Non-equilibrium phase separation with reactions: A canonical model and its behaviour
• A mechanism for cell motility by active polar gels
• Margination of white blood cells - a computational approach by a hydrodynamic phase field model
• Doubly Degenerate Diffuse Interface Models of Surface Diffusion
• Multiphase field models for collective cell migration
• Topological and geometrical quantities in active cellular structures

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• Effects of local curvature on epithelia tissue -- coordinated rotational movement and other spatiotemporal arrangements
• Minimal cellular automaton model with heterogeneous cell sizes predicts epithelial colony growth
• Motion Ordering in Cellular Polar-polar and Polar-nonpolar Interactions