Measuring kinetic parameters using quantum plasmonic sensing
arXiv:2107.06214 · doi:10.1103/PhysRevA.105.032619
Abstract
The measurement of parameters that describe kinetic processes is important in the study of molecular interactions. It enables a deeper understanding of the physical mechanisms underlying how different biological entities interact with each other, such as viruses with cells, vaccines with antibodies, or new drugs with specific diseases. In this work, we study theoretically the use of quantum sensing techniques for measuring the kinetic parameters of molecular interactions. The sensor we consider is a plasmonic resonance sensor -- a label-free photonic sensor that is one of the most widely used in research and industry. The first type of interaction we study is the antigen BSA interacting with antibody IgG1, which provides a large sensor response. The second type is the enzyme carbonic anhydrase interacting with the tumor growth inhibitor benzenesulfonamide, which produces a small sensor response. For both types of interaction we consider the use of two-mode Fock states, squeezed vacuum states and squeezed displaced states. We find that these quantum states offer an enhancement in the measurement precision of kinetic parameters when compared to that obtained with classical light. The results may help in the design of more precise quantum-based sensors for studying kinetics in the life sciences.
18 pages, 14 figures, appendix
References in corpus (22)
- Strong low-frequency quantum correlations from a four-wave mixing amplifier
- Ultrasensitive measurement of MEMS cantilever displacement sensitivity below the shot noise limit
- Generation of spatially broadband twin beams for quantum imaging
- Measurement of the decay of Fock states in a superconducting quantum circuit
- Sub-shot-noise photon-number correlation in mesoscopic twin-beam of light
- Quantum Plasmonic Sensors
- Quantum-Enhanced Plasmonic Sensing
- Photon number correlation for quantum enhanced imaging and sensing
- Field locked to Fock state by quantum feedback with single photon corrections
- Quantum-limited loss sensing: Multiparameter estimation and Bures distance between loss channels
- Role of the phase-matching condition in non-degenerate four-wave mixing in hot vapors for the generation of squeezed states of light
- Photon-number distributions of twin beams generated in spontaneous parametric down-conversion and measured by an intensified CCD camera
- Quantum networks generation based on four-wave mixing
- Deterministic Generation of Large Fock States
- Quantum plasmonic sensing using single photons
- Quantum noise reduction in intensity-sensitive surface plasmon resonance sensors
- Imaging using quantum noise properties of light
- On-demand generation of higher-order Fock states in quantum-dot--cavity systems
- Deterministic single-atom source of quasi-superradiant -photon pulses
- How many principles does it take to change a light bulb ... into a laser?
- Experimental Fock-State Bunching Capability of Non-Ideal Single-Photon States
- Exact calculation of stimulated emission driven by pulsed light
Cited by in corpus (5)
- Experimental measurement of kinetic parameters using quantum plasmonic sensing
- Quantum scale estimation
- Experimental plasmonic sensing of malaria using an aluminum metasurface
- On the role of symmetry and geometry in global quantum sensing
- Stationary two-qubit entanglement mediated by one-dimensional plasmonic nanoarrays