Modelling and simulation of electrical propagation in transmural slabs of scarred left ventricle tissue
arXiv:2105.09112
Abstract
We report three-dimensional and time-dependent numerical simulations of the propagation of electrical action potentials in a model of rabbit ventricular tissue. The simulations are performed using a finite-element method for the solution of the monodomain equations of cardiac electrical excitation. The parameters of a detailed ionic ventricular cell model are re-fitted to available experimental data and the model is then used for the description of the transmembrane current and calcium dynamics. A region with reduced conductivity is introduced to model a myocardial infarction scar. Electrical activation times and density maps of the transmembrane voltage are computed and compared with experimental measurements in rabbit preparations with myocardial infarction obtained by a panoramic optical mapping method.
Published in the proceedings of the 6th European Conference on Computational Mechanics (ECCM 6) 7th European Conference on Computational Fluid Dynamics (ECFD 7) 11-15 June 2018, Glasgow, UK: http://congress.cimne.com/eccm_ecfd2018