Structural anomalies in brain networks induce dynamical pacemaker effects
arXiv:2011.00911 · doi:10.1063/5.0006207
Abstract
Dynamical effects on healthy brains and brains affected by tumor are investigated via numerical simulations. The brains are modeled as multilayer networks consisting of neuronal oscillators, whose connectivities are extracted from Magnetic Resonance Imaging (MRI) data. The numerical results demonstrate that the healthy brain presents chimera-like states where regions with high white matter concentrations in the direction connecting the two hemispheres act as the coherent domain, while the rest of the brain presents incoherent oscillations. To the contrary, in brains with destructed structure traveling waves are produced initiated at the region where the tumor is located. These areas act as the pacemaker of the waves sweeping across the brain. The numerical simulations are performed using two neuronal models: a) the FitzHugh-Nagumo model and b) the Leaky Integrate-and-Fire model. Both models give consistent results regarding the chimera-like oscillations in healthy brains and the pacemaker effect in the tumorous brains. These results are considered as a starting point for further investigation in the detection of tumors with small sizes before becoming discernible on the MRI recordings, as well as in tumor development and evolution.
14 pages, 11 figures
References in corpus (25)
- Chimera States for Coupled Oscillators
- Chimera states: Coexistence of coherence and incoherence in networks of coupled oscillators
- Chimera States in Mechanical Oscillator Networks
- Coexistence of Coherence and Incoherence in Nonlocally Coupled Phase Oscillators
- When Nonlocal Coupling Between Oscillators Becomes Stronger: Patched Synchrony or Multi-Chimera States
- Coexistence of synchrony and incoherence in oscillatory media under nonlinear global coupling
- Robustness of chimera states for coupled FitzHugh-Nagumo oscillators
- Chimera states in networks of nonlocally coupled Hindmarsh-Rose neuron models
- Chimera states in uncoupled neurons induced by a multilayer structure
- Cognitive chimera states in human brain networks
- Chimera states in brain networks: empirical neural vs. modular fractal connectivity
- Instability of synchronized motion in nonlocally coupled neural oscillators
- Controlling seizure propagation in large-scale brain networks
- Chimera patterns in two-dimensional networks of coupled neurons
- Intermittent chaotic chimeras for coupled rotators
- Chimera states in population dynamics: networks with fragmented and hierarchical connectivities
- Chimera in a neuronal network model of the cat brain
- Chimeras in SQUID Metamaterials
- Robust chimera states in SQUID metamaterials with local interactions
- Time-delayed feedback control of coherence resonance chimeras
- Weak multiplexing in neural networks: Switching between chimera and solitary states
- Partial synchronization in empirical brain networks as a model for unihemispheric sleep
- Chimeras in Leaky Integrate-and-Fire Neural Networks: Effects of Reflecting Connectivities
- Control of amplitude chimeras by time delay in dynamical networks
- Riddling: Chimera's dilemma