Rheology of sliding leaflets in coarse-grained DSPC lipid bilayers

Abstract

Amphiphilic lipid bilayers modify the friction properties of the surfaces on top of which they are deposited. In particular, the measured sliding friction coefficient is significantly reduced compared with the native surface. We investigate in this work the friction properties of a numerical coarse-grained model of DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine) lipid bilayer subject to longitudinal shear. The interleaflet friction coefficient is obtained from out-of-equilibrium pulling and relaxation simulations. In particular, we gain access to the transient viscoelastic response of a sheared bilayer. The bilayer mechanical response is found to depend significantly on the membrane physical state, with evidence in favor of a linear response regime in the fluid but not in the gel region.

22 pages including Supplementary Information, 26 figures

References in corpus (4)

• Canonical sampling through velocity-rescaling
• Subdiffusion and lateral diffusion coefficient of lipid atoms and molecules in phospholipid bilayers
• Nanorheology of interfacial water during ice gliding
• Controlling interactions in supported bilayers from weak electrostatic repulsion to high osmotic pressure