What do we know about DNA mechanics so far?
arXiv:2006.00822 · doi:10.1016/j.sbi.2020.05.010
Abstract
The DNA molecule, apart from carrying the genetic information, plays a crucial role in a variety of biological processes and find applications in drug design, nanotechnology and nanoelectronics. The molecule undergoes significant structural transitions under the influence of forces due to physiological and non-physiological environments. Here, we summarize the insights gained from simulations and single-molecule experiments on the structural transitions and mechanics of DNA under force, as well as its elastic properties, in various environmental conditions, and discuss appealing future directions.
Review Article, Accepted for publication in Current Opinion in Structural Biology
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Cited by in corpus (8)
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- Mechanical properties of DNA and DNA nanostructures: comparison of atomistic, martini and oxDNA
- Mechanical properties of Nucleic Acids and the non-local Twistable Wormlike Chain model
- Coarse-graining DNA: Symmetry, non-local elasticity and persistence length
- Fine-tuning the DNA conductance by intercalation of drug molecules
- DNA versus RNA -- which shows higher electronic conduction?
- Probing the microscopic structure and flexibility of oxidized DNA by molecular simulations
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