Water-assisted electronic transport in graphene nanogaps for DNA sequencing
arXiv:1908.02258
Abstract
Innovative methodologies for reliably and inexpensively sequencing DNA can lead to a new era of personalized medicine. In this work, we performed a theoretical investigation of a nanogap-based all electronic DNA sequencing device. To do so, we used a nitrogen-terminated nanogap on a graphene sheet with the environment fully taken into account. Our investigation is performed using a hybrid methodology combining quantum and classical mechanics coupled to non-equilibrium Green's functions for solving the electron transport across the device. The obtained results show that the DNA nucleotides can be both detected and distinguished in such device, which indicates that it can be used as a DNA sequencing device providing very high sensitivity and selectivity. Furthermore, our results show that water plays a major role in electronic transport in nanoscopic tunneling devices, not only from an electrostatics point of view, but also by providing states that significantly increase the conductance in nanogap-based DNA sequencing devices.
arXiv comment17 pages, 5 figures
References in corpus (6)
- First-Principles Based Matrix-Green's Function Approach to Molecular Electronic Devices: General Formalism
- Transmission eigenchannels from non-equilibrium Green's functions
- Functionalized nanopore-embedded electrodes for rapid DNA sequencing
- Finite-bias electronic transport of molecules in water solution
- An efficient method for computing the electronic transport properties of a multi-terminal system
- DNA-Graphene Interactions During Translocation Through Nanogaps