Quantum noise limited nanoparticle detection with exposed-core fiber
arXiv:1904.12020 · doi:10.1364/OE.27.018601
Abstract
Label-free biosensors are important tools for clinical diagnostics and for studying biology at the single molecule level. The development of optical label-free sensors has allowed extreme sensitivity, but can expose the biological sample to photodamage. Moreover, the fragility and complexity of these sensors can be prohibitive to applications. To overcome these problems, we develop a quantum noise limited exposed-core fiber sensor providing robust platform for label-free biosensing with a natural path toward microfluidic integration. We demonstrate the detection of single nanoparticles down to 25 nm in radius with optical intensities beneath known biophysical damage thresholds.
arXiv comment11 pages, 6 figures
References in corpus (5)
- Fast, label-free tracking of single viruses and weakly scattering nanoparticles in a nano-fluidic optical fiber
- Detection of Nanoparticles with a Frequency Locked Whispering Gallery Mode Microresonator
- Label-free optical detection of single enzyme-reactant reactions and associated conformational changes
- Non-destructive profilometry of optical nanofibres
- Tapered nanofiber trapping of high-refractive-index nanoparticles