Orientational transition and complexation of DNA with anionic membranes: weak and intermediate electrostatic coupling
arXiv:1903.05950 · doi:10.1103/PhysRevE.99.062501
Abstract
We characterize the role of charge correlations in the adsorption of a short, rod-like anionic polyelectrolyte onto a similarly charged membrane. Our theory reveals two different mechanisms driving the like-charge polyelectrolyte-membrane complexation: in weakly charged membranes, repulsive polyelectrolyte-membrane interactions lead to the interfacial depletion and a parallel orientation of the polyelectrolyte with respect to the membrane; while in the intermediate membrane charge regime, the interfacial counterion excess gives rise to an attractive "salt-induced" image force. This furthermore results in an orientational transition from a parallel to a perpendicular configuration and a subsequent short-ranged like-charge adsorption of the polyelectrolyte to the substrate. A further increase of the membrane charge engenders a charge inversion, originating from surface-induced ionic correlations, that act as a separate mechanism capable of triggering the like-charge polyelectrolyte-membrane complexation over an extended distance interval from the membrane surface. The emerging picture of this complexation phenomenon identifies the interfacial "salt-induced" image forces as a powerful control mechanism in polyelectrolyte-membrane complexation.
References in corpus (16)
- Beyond Poisson-Boltzmann: Fluctuations and Correlations
- Strong-Coupling Theory for Counter-Ion Distributions
- Perspective: Coulomb fluids -- weak coupling, strong coupling, in between and beyond
- Complexation of a polyelectrolyte with oppositely charged spherical macroions: Giant inversion of charge
- Collapse of Stiff Polyelectrolytes due to Counterion Fluctuations
- Counter-ion release and electrostatic adsorption
- When Do Like Charges Attract?
- Dressed Counterions: Strong Electrostatic Coupling in the Presence of Salt
- Meso-scale computer modeling of lipid-DNA complexes for gene therapy
- Role of Multipoles in Counterion-Mediated Interactions between Charged Surfaces: Strong and Weak Coupling
- Electrostatic correlations in inhomogeneous charged fluids beyond loop expansion
- Simulations of Polyelectrolyte Adsorption to a Dielectric Like-Charged Surface
- Multivalent Ion-Activated Protein Adsorption Reflecting Bulk Reentrant Behavior
- Attraction between Neutral Dielectrics Mediated by Multivalent Ions in an Asymmetric Ionic Fluid
- Correlation-induced DNA adsorption on like-charged membranes
- Conformational Properties of an Adsorbed Charged Polymer