paper

Human-sized Magnetic Particle Imaging for Brain Applications

arXiv:1810.07987 · doi:10.1038/s41467-019-09704-x

Abstract

Determining the brain perfusion is an important task for the diagnosis and treatment of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis and treatment, there is a high risk of restenosis or rebleeding such that patients need intense and frequent attention in the days after treatment. Within this work, we will present a diagnostic tomographic imager that allows access to brain perfusion information quantitatively in short intervals. The imager is the first functional magnetic particle imaging device for brain imaging on a human-scale. It is highly sensitive and allows the detection of an iron concentration of 14.7 ng /ml (263 pmol\ml), which is the lowest iron concentration imaged by MPI so far. The imager is self-shielded and can be used in unshielded environments such as intensive care units. In combination with the low technical requirements this opens up a whole variety of possible medical applications and would allow monitoring possibilities on the stroke and intensive care units.

12 Pages (plus 5 pages methods) , 6 figures, 4 videos

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