Optimal Distributed Control of a Cahn-Hilliard-Darcy System with Mass Sources

Abstract

In this paper, we study an optimal control problem for a two-dimensional Cahn-Hilliard-Darcy system with mass sources that arises in the modeling of tumor growth. The aim is to monitor the tumor fraction in a finite time interval in such a way that both the tumor fraction, measured in terms of a tracking type cost functional, is kept under control and minimal harm is inflicted to the patient by administering the control, which could either be a drug or nutrition. We first prove that the optimal control problem admits a solution. Then we show that the control-to-state operator is Fréchet differentiable between suitable Banach spaces and derive the first-order necessary optimality conditions in terms of the adjoint variables and the usual variational inequality.

References in corpus (2)

• A multiphase Cahn-Hilliard-Darcy model for tumour growth with necrosis
• Erratum: "On the nonlocal Cahn-Hilliard-Brinkman and Cahn-Hilliard-Hele-Shaw systems" [Comm. Pure Appl. Anal. 15 (2016), 299-317]

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