Energy consumption and cooperation for optimal sensing

Abstract

The reliable detection of environmental molecules in the presence of noise is an important cellular function, yet the underlying computational mechanisms are not well understood. We introduce a model of two interacting sensors which allows for the principled exploration of signal statistics, cooperation strategies and the role of energy consumption in optimal sensing, quantified through the mutual information between the signal and the sensors. Here we report that in general the optimal sensing strategy depends both on the noise level and the statistics of the signals. For joint, correlated signals, energy consuming (nonequilibrium), asymmetric couplings result in maximum information gain in the low-noise, high-signal-correlation limit. Surprisingly we also find that energy consumption is not always required for optimal sensing. We generalise our model to incorporate time integration of the sensor state by a population of readout molecules, and demonstrate that sensor interaction and energy consumption remain important for optimal sensing.

arXiv comment9 pages, 5 figures, Forthcoming in Nature Communications

References in corpus (15)

• The Energetic Costs of Cellular Computation
• Information transmission in genetic regulatory networks: a review
• Optimizing information flow in small genetic networks. I
• Optimizing information flow in small genetic networks. II: Feed forward interactions
• Intrinsic limits to gene regulation by global crosstalk
• Physical limit to concentration sensing amid spurious ligands
• Chemical sensing by nonequilibrium cooperative receptors
• Dynamics of cooperativity in chemical sensing among cell-surface receptors
• Landauer in the age of synthetic biology: energy consumption and information processing in biochemical networks
• Receptor crosstalk improves concentration sensing of multiple ligands
• Know the single-receptor sensing limit? Think again
• Optimal receptor-cluster size determined by intrinsic and extrinsic noise
• Stochastic proofreading mechanism alleviates crosstalk in transcriptional regulation
• The accuracy of telling time via oscillatory signals
• Extrinsic and intrinsic correlations in molecular information transmission

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