Principal Process Analysis of dynamic GlucoCEST MRI data

Abstract

GlucoCEST is an MRI contrast enhancement technique sensitive to the concentration of sugar in the tissue. Because of a differencein metabolism, it is thought that tumors consume more sugar than normal tissue. However, glucose metabolism is complex and depends onmany processes, which are all important to understand the origin of the measured signal. To achieve this goal we apply here a process analysismethod to a deterministic system describing the metabolism of glucose in the tissue.