Confluent and non-confluent phases in a model of cell tissue

Abstract

The Voronoi-based cellular model is highly successful in describing the motion of two-dimensional confluent cell tissues. In the homogeneous version of this model, the energy of each cell is determined solely by its geometric shape and size, and the interaction between adjacent cells is a byproduct of this additive energy. We generalize this model so as to allow zero or partial contact between cells. We identify several phases, two of which (solid confluent and liquid confluent) were found in previous studies that imposed confluency but others that are novel. Transitions in this model may be relevant for understanding both normal development as well as cancer metastasis.

arXiv comment15 figures + 2 videos

References in corpus (5)

• A density-independent glass transition in biological tissues
• Motility-driven glass and jamming transitions in biological tissues
• Multicellular Tumor Spheroid in an off-lattice Voronoi/Delaunay cell model
• Glassy dynamics of athermal self-propelled particles: Computer simulations and a nonequilibrium microscopic theory
• Interacting Brownian dynamics in a nonequilibrium particle bath

Cited by in corpus (14)

• Physical Models of Collective Cell Migration
• A minimal-length approach unifies rigidity in under-constrained materials
• Solid-Liquid Transition of Deformable and Overlapping Active Particles
• Multicellular rosettes drive fluid-solid transition in epithelial tissues
• Mechanical heterogeneity in tissues promotes rigidity and controls cellular invasion
• Interplay of curvature and rigidity in shape-based models of confluent tissue
• Analogies between growing dense active matter and soft driven glasses
• Tissue flow induces cell shape changes during organogenesis
• Quantifying the link between local structure and cellular rearrangements using information in models of biological tissues
• Poisson-bracket formulation of the dynamics of fluids of deformable particles
• Bridging the Gap Between Collective Motility and Epithelial-Mesenchymal Transitions through the Active Finite Voronoi Model
• Rigidity of Epithelial Tissues as a Double Optimization Problem
• Role of intercellular adhesion in modulating tissue fluidity
• Leader-cell-driven epithelial sheet fingering