In vivo high resolution human retinal imaging with wavefront correctionless full-field OCT

Abstract

As the lateral resolution of FFOCT with spatially incoherent illumination has been shown to be insensitive to aberrations, we demonstrate high resolution en face full-field OCT (FFOCT) retinal imaging without wavefront correction in the human eye in vivo for the first time. A combination of FFOCT with spectral-domain OCT (SDOCT) is applied for real-time matching of the optical path lengths (OPL) of FFOCT. Through the real-time cross-sectional SDOCT images, the OPL of the FFOCT reference arm is matched with different retinal layers in the FFOCT sample arm. Thus, diffraction limited FFOCT images of multiple retinal layers are acquired at both the near periphery and the fovea. The en face FFOCT retinal images reveal information about various structures such as the nerve fiber orientation, the blood vessel distribution, and the photoreceptor mosaic.

References in corpus (1)

• Spatially incoherent illumination interferometry: a PSF almost insensitive to aberrations

Cited by in corpus (6)

• Motion artifact removal and signal enhancement to achieve in vivo dynamic full field OCT
• Real-time, non-contact, cellular imaging and angiography of human cornea and limbus with common-path Full-field/SDOCT
• Unified k-space theory of optical coherence tomography
• Curved-Full-Field OCT for high-resolution imaging of living human retina over a large field-of-view
• Comparative analysis of full-field OCT and optical transmission tomography
• Optical phase modulation by natural eye movements: application to time-domain FF-OCT image retrieval