Generic transport mechanisms for molecular traffic in cellular protrusions
arXiv:1703.02536 · doi:10.1103/PhysRevLett.118.128101
Abstract
Transport of molecular motors along protein filaments in a half-closed geometry is a common feature of biologically relevant processes in cellular protrusions. Using a lattice gas model we study how the interplay between active and diffusive transport and mass conservation leads to localised domain walls and tip localisation of the motors. We identify a mechanism for task sharing between the active motors (maintaining a gradient) and the diffusive motion (transport to the tip), which ensures that energy consumption is low and motor exchange mostly happens at the tip. These features are attributed to strong nearest-neighbour correlations that lead to a strong reduction of active currents, which we calculate analytically using an exact moment-identity, and might prove useful for the understanding of correlations and active transport also in more elaborate systems.
5 pages, 3 figures, and Supplemental Material
References in corpus (13)
- Nonequilibrium Steady States of Matrix Product Form: A Solver's Guide
- Phase Coexistence in Driven One Dimensional Transport
- The Totally Asymmetric Simple Exclusion Process with Langmuir Kinetics
- Traffic of molecular motors through tube-like compartments
- Matrix representation of the stationary measure for the multispecies TASEP
- Asymmetric Coupling in Two-Channel Simple Exclusion Processes
- Traffic jams induced by rare switching events in two-lane transport
- Phase diagram of two-lane driven diffusive systems
- Molecular Mechanisms for Microtubule Length Regulation by Kinesin-8 and XMAP215 Proteins
- Domain wall delocalization, dynamics and fluctuations in an exclusion process with two internal states
- Inhomogeneous Coupling in Two-Channel Asymmetric Simple Exclusion Processes
- A nonequilibrium diffusion and capture mechanism ensures tip-localization of regulating proteins on dynamic filaments
- Will jams get worse when slow cars move over?