Monitoring Microtubule Mechanical Vibrations via Optomechanical Coupling
arXiv:1612.07061 · doi:10.1103/PhysRevE.96.012404
Abstract
The possible disruption of a microtubule during mitosis can control the duplication of a cancer cell. Cancer detection and treatment may be possible based on the detection and control of microtubule mechanical oscillations in cells through external fields (e.g. electromagnetic or ultrasound). However, little is known about the dynamic (high-frequency) mechanical properties of microtubules. Here we propose to control the vibrations of a doubly clamped microtubule by tip electrodes and to detect its motion via the optomechanical coupling between the vibrational modes of the microtubule and an optical cavity. In the presence of a red-detuned strong pump laser, this coupling leads to optomechanical induced transparency of an optical probe field, which can be detected with state-of the art technology. The center frequency and linewidth of the transparency peak give the resonance frequency and damping rate of the microtubule respectively, while the height of the peak reveals information about the microtubule-cavity field coupling. Our method should yield new knowledge about the physical properties of microtubules, which will enhance our capability to design physical cancer treatment protocols as alternatives to chemotherapeutic drugs.
References in corpus (29)
- Cavity Optomechanics
- Sideband Cooling Micromechanical Motion to the Quantum Ground State
- Optomechanically induced transparency
- Electromagnetically Induced Transparency and Slow Light with Optomechanics
- Towards quantum superpositions of a mirror
- Bidirectional and efficient conversion between microwave and optical light
- The Electromagnetically Induced Transparency in Mechanical Effects of Light
- Analysis of radiation-pressure induced mechanical oscillation of an optical microcavity
- Near-field cavity optomechanics with nanomechanical oscillators
- Microwave Quantum Illumination
- Quantum Illumination at the Microwave Wavelengths
- Mechanical systems in the quantum regime
- Elastic properties of grafted microtubules
- Microwave amplification with nanomechanical resonators
- Reversible optical to microwave quantum interface
- Precision measurement of charge number with optomechanically induced transparency
- Entangling optical and microwave cavity modes by means of a nanomechanical resonator
- Demonstration of ultra-high-Q small mode volume toroid microcavities on a chip
- Quantum-Limited Amplification via Reservoir Engineering
- Precision measurement of the environmental temperature by tunable double optomechanically induced transparency with a squeezed field
- Optomechanical superpositions via nested interferometry
- Steady-state negative Wigner functions of nonlinear nanomechanical oscillators
- Opto-mechanical micro-macro entanglement
- Narrowing the filter cavity bandwidth via optomechanical interaction
- Nonlinear nanomechanical resonators for quantum optoelectromechanics
- Phonon Josephson Junction with Nanomechanical Resonators
- Tunable mechanical coupling between driven microelectromechanical resonators
- Resolving controversy of unusually high refractive index of tubulin
- Induced transparency in optomechanically coupled resonators