Broken Detailed Balance of Filament Dynamics in Active Networks

Abstract

Myosin motor proteins drive vigorous steady-state fluctuations in the actin cytoskeleton of cells. Endogenous embedded semiflexible filaments such as microtubules, or added filaments such as single-walled carbon nanotubes are used as novel tools to non-invasively track equilibrium and non-equilibrium fluctuations in such biopolymer networks. Here we analytically calculate shape fluctuations of semiflexible probe filaments in a viscoelastic environment, driven out of equilibrium by motor activity. Transverse bending fluctuations of the probe filaments can be decomposed into dynamic normal modes. We find that these modes no longer evolve independently under non-equilibrium driving. This effective mode coupling results in non-zero circulatory currents in a conformational phase space, reflecting a violation of detailed balance. We present predictions for the characteristic frequencies associated with these currents and investigate how the temporal signatures of motor activity determine mode correlations, which we find to be consistent with recent experiments on microtubules embedded in cytoskeletal networks.

6 Pages, 4 figures

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Cited by in corpus (43)

• Broken detailed balance and non-equilibrium dynamics in living systems
• Quantifying dissipation using fluctuating currents
• Inferring broken detailed balance in the absence of observable currents
• Time-(ir)reversibility in active matter: from micro to macro
• Improved bounds on entropy production in living systems
• Theoretical Perspectives on Biological Machines
• Learning force fields from stochastic trajectories
• Origins and diagnostics of the nonequilibrium character of active systems
• Entropy Production Rate is Maximized in Non-Contractile Actomyosin
• Enhanced diffusion, swelling and slow reconfiguration of a single chain in non-Gaussian active bath
• Exact Coarse Graining Preserves Entropy Production out of Equilibrium
• Learning entropy production via neural networks
• Distribution of the time of the maximum for stationary processes
• Elasticity-based polymer sorting in active fluids: A Brownian dynamics study
• Non-equilibrium scaling behaviour in driven soft biological assemblies
• Inference in non-equilibrium systems from incomplete information: the case of linear systems and its pitfalls
• Active dynamics and spatially coherent motion in chromosomes subject to enzymatic force dipoles
• Learning the Non-Equilibrium Dynamics of Brownian Movies
• Experimental metrics for detection of detailed balance violation
• Nonequilibrium dynamics of probe filaments in actin-myosin networks
• Mathematical, Thermodynamical, and Experimental Necessity for Coarse Graining Empirical Densities and Currents in Continuous Space
• Inertial effects on the Brownian gyrator
• Morphological and dynamical properties of semiflexible filaments driven by molecular motors
• Coarse Graining Empirical Densities and Currents in Continuous-Space Steady States
• Non-equilibrium probability flux of a thermally driven micromachine
• Non-Gaussian anomalous dynamics in systems of interacting run-and-tumble particles
• Scale dependence of mechanics and dynamics of active gels with increasing motor concentration
• Perspective: Time irreversibility in systems observed at coarse resolution
• Irreversibility in linear systems with colored noise
• Stochastic resetting and first arrival subjected to Gaussian noise and Poisson white noise
• Activity-dependent self-regulation of viscous length scales in biological systems
• Variance sum rule: proofs and solvable models
• Scaling behavior of non-equilibrium measures in internally driven elastic assemblies
• Non-equilibrium dynamics of isostatic spring networks
• Mesoscopic non-equilibrium measures can reveal intrinsic features of the active driving
• From predicting to learning dissipation from pair correlations of active liquids
• Irreversibility and entropy production of a thermally driven micromachine
• Stochastic line integrals and stream functions as metrics of irreversibility and heat transfer
• Universal Casimir attraction between filaments at the cell scale
• Nonequilibrium Probability Currents in Optically-Driven Colloidal Suspensions
• Attaining entropy production and dissipation maps from Brownian movies via neural networks
• Non-equilibrium fluctuations of a semi-flexible filament driven by active cross-linkers
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