A complex network analysis of hypertension-related genes
arXiv:1601.07192 · doi:10.1016/j.physa.2013.09.054
Abstract
In this paper, a network of hypertension-related genes is constructed by analyzing the correlations of gene expression data among the Dahl salt-sensitive rat and two consomic rat strains. The numerical calculations show that this sparse and assortative network has small-world and scale-free properties. Further, 16 key hub genes (Col4a1, Lcn2, Cdk4, etc.) are determined by introducing an integrated centrality and have been confirmed by biological/medical research to play important roles in hypertension.
13 pages, 6 figures, 3 tables; a revised version of an article published in Physica A: Statistical Mechanics and its Applications