Redundancy in the information transmission in a two-step cascade

Abstract

We present a stochastic framework to study signal transmission in a generic two-step cascade $\text{S}\to \text{X}\to \text{Y}$. Starting from a set of Langevin equations obeying Gaussian noise processes we calculate the variance and covariance while considering both linear and nonlinear production terms for different biochemical species of the cascade. These quantities are then used to calculate the net synergy within the purview of partial information decomposition. We show that redundancy in information transmission is essentially an important consequence of Markovian property of the two-step cascade motif. We also show that redundancy increases fidelity of the signalling pathway.

arXiv commentRevised version, 7 pages, 2 figures

References in corpus (15)

• Information flow and optimization in transcriptional control
• Exploration of synergistic and redundant information sharing in static and dynamical Gaussian systems
• Information transmission in genetic regulatory networks: a review
• Signal detection, modularity and the correlation between extrinsic and intrinsic noise in biochemical networks
• Optimizing information flow in small genetic networks. I
• Optimal signal processing in small stochastic biochemical networks
• Information capacity of genetic regulatory elements
• Optimizing information flow in small genetic networks. II: Feed forward interactions
• The role of input noise in transcriptional regulation
• Mutual information in time-varying biochemical systems
• Exact results for noise power spectra in linear biochemical reaction networks
• The effect of feedback on the fidelity of information transmission of time-varying signals
• The linear-noise approximation and the chemical master equation exactly agree up to second-order moments for a class of chemical systems
• Role of relaxation time scale in noisy signal transduction
• Role of functionality in two-component signal transduction: A stochastic study

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• The coherent feed-forward loop acts as an efficient information transmitting motif
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• Characterizing the non-monotonic behavior of mutual information along biochemical reaction cascades
• Information transmission in a two-step cascade: Interplay of activation and repression