Long-lived anomalous thermal diffusion induced by elastic cell membranes on nearby particles

Abstract

The physical approach of a small particle (virus, medical drug) to the cell membrane represents the crucial first step before active internalization and is governed by thermal diffusion. Using a fully analytical theory we show that the stretching and bending of the elastic membrane by the approaching particle induces a memory in the system which leads to anomalous diffusion, even though the particle is immersed in a purely Newtonian liquid. For typical cell membranes the transient subdiffusive regime extends beyond 10 ms and can enhance residence times and possibly binding rates up to 50\%. Our analytical predictions are validated by numerical simulations.

13 pages and 5 figures. The Supporting Information is included. Manuscript accepted for publication in Phys. Rev. E

References in corpus (5)

• Efficient and accurate simulations of deformable particles immersed in a fluid using a combined immersed boundary lattice Boltzmann finite element method
• The mechanism of phagocytosis: two stages of engulfment
• Anisotropic memory effects in confined colloidal diffusion
• Elastohydrodynamics of a sliding, spinning and sedimenting cylinder near a soft wall
• Persistent correlation of constrained colloidal motion

Cited by in corpus (35)

• Leveraging Collective Effects in Externally Driven Colloidal Suspensions: Experiments and Simulations
• Clustering of microscopic particles in constricted blood flow
• Rotation of an immersed cylinder sliding near a thin elastic coating
• State diagram of a three-sphere microswimmer in a channel
• Particle mobility between two planar elastic membranes: Brownian motion and membrane deformation
• Mobility of an axisymmetric particle near an elastic interface
• Anti-margination of microparticles and platelets in the vicinity of branching vessels
• Hydrodynamic interaction between particles near elastic interfaces
• A reciprocal theorem for the prediction of the normal force induced on a particle translating parallel to an elastic membrane
• Brownian motion near an elastic cell membrane: A theoretical study
• Membrane penetration and trapping of an active particle
• Computational modeling of active deformable membranes embedded in 3D flows
• Hydrodynamic mobility of a solid particle nearby a spherical elastic membrane. I. Axisymmetric motion
• Frequency-dependent higher-order Stokes singularities near a planar elastic boundary: implications for the hydrodynamics of an active microswimmer near an elastic interface
• Hydrodynamic mobility of a sphere moving on the centerline of an elastic tube
• Hydrodynamic coupling and rotational mobilities near planar elastic membranes
• Creeping motion of a solid particle inside a spherical elastic cavity
• Slow rotation of a spherical particle inside an elastic tube
• Hydrodynamic mobility of a solid particle nearby a spherical elastic membrane. II. Asymmetric motion
• Axisymmetric flow due to a Stokeslet near a finite-sized elastic membrane
• Creeping motion of a solid particle inside a spherical elastic cavity. II. Asymmetric motion
• Elastohydrodynamic wake and wave resistance
• The hydrodynamics of slender swimmers near deformable interfaces
• Steady azimuthal flow field induced by a rotating sphere near a rigid disk or inside a gap between two coaxially positioned rigid disks
• Theory of active particle penetration through a planar elastic membrane
• Elasto-inertial rectification of oscillatory flow in an elastic tube
• Asymmetric Stokes flow induced by a transverse point-force acting near a finite-sized elastic membrane
• Mass changes the diffusion coefficient of particles with ligand-receptor contacts in the overdamped limit
• On force balance in Brinkman fluids under confinement
• Internal sites of actuation and activation in thin elastic films and membranes of finite thickness
• Hydrodynamics of a disk in a thin film of weakly nematic fluid subject to linear friction
• Enhanced molecular diffusion near a soft fluctuating membrane
• Dynamics of a simple model microswimmer in an anisotropic fluid: implications for alignment behavior and active transport in a nematic liquid crystal
• Microparticle Brownian Motion near an Air-Water Interface Governed by Direction-Dependent Boundary Conditions
• Enhancement and Suppression of Active Particle Movement Due to Membrane Deformations