Enhanced diffusion of molecular motors in the presence of adenosine triphosphate and external force

Abstract

The diffusion of a molecular motor in the presence of a constant external force is considered on the basis of a simple theoretical model. The motor is represented by a Brownian particle moving in a series of parabolic potentials placed periodically on a line, and the potential is switched stochastically from one parabola to another by a chemical reaction, which corresponds to the ATP hydrolysis or synthesis in motor proteins. It is found that the diffusion coefficient as a function of the force exhibits peaks. The mechanism of this diffusion enhancement and the possibility of observing it in F1-ATPase, a biological rotary motor, are discussed.

22 pages, 19 figues

References in corpus (7)

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Cited by in corpus (5)

• Universal bound on the efficiency of molecular motors
• Large Deviation Function for a Driven Underdamped Particle in a Periodic Potential
• Variational control forces for enhanced sampling of nonequilibrium molecular dynamics simulations
• Diffusion Enhancement of Brownian Motors Revealed by a Solvable Model
• Inverse thermodynamic uncertainty relation and entropy production