Brownian dynamics simulations of an idealized chemical reaction network under spatial confinement and crowding conditions
arXiv:1510.05474 · doi:10.1103/PhysRevE.94.042306
Abstract
We investigate, via Brownian dynamics simulations, the reaction dynamics of a simple, non-linear chemical network (the Willamowski-Rossler network) under spatial confinement and crowding conditions. Our results show that the presence of inert crowders has a non-nontrivial effect on the dynamics of the network and, consequently, that effective modeling efforts aiming at a general understanding of the behavior of biochemical networks in vivo should be stochastic in nature and based on an explicit representation of both spatial confinement and macromolecular crowding.
20 pages, 8 figures, 1 table