Nucleobase-functionalized graphene nanoribbons for accurate high-speed DNA sequencing
arXiv:1509.04778 · doi:10.1039/c5nr07061a
Abstract
We propose a water-immersed nucleobase-functionalized suspended graphene nanoribbon as an intrinsically selective device for nucleotide detection. The proposed sensing method combines Watson-Crick selective base pairing with graphene's capacity for converting anisotropic lattice strain to changes in an electrical current at the nanoscale. Using detailed atomistic molecular dynamics simulations, we study sensor operation at ambient conditions. We combine simulated data with theoretical arguments to estimate the levels of measurable electrical signal variation in response to strains and determine that the proposed sensing mechanism shows significant promise for realistic DNA sensing devices without the need for advanced data processing, or highly restrictive operational conditions.
References in corpus (10)
- Thermal properties of graphene: Fundamentals and applications
- Graphene: A sub-nanometer trans-electrode membrane
- Optimized Tersoff and Brenner empirical potential parameters for lattice dynamics and phonon thermal transport in carbon nanotubes and graphene
- DNA Translocation through Graphene Nanopores
- Tuning carbon nanotube bandgaps with strain
- Physical approaches to DNA sequencing and detection
- Transverse Electronic Transport through DNA Nucleotides with Functionalized Graphene Electrodes
- Manipulation of graphene's dynamic ripples by local harmonic out-of-plane excitation
- Nanomechanical displacement detection using coherent transport in ordered and disordered graphene nanoribbon resonators
- Strain-induced modifications of transport in gated graphene nanoribbons
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- Relaxation-limited electronic currents in extended reservoir simulations
- Nanopores in atomically thin 2D nanosheets limit aqueous ssDNA transport