Anomalous transport of subdiffusing cargos by single kinesin motors: the role of mechanochemical coupling and anharmonicity of tether

Abstract

Here we generalize our previous model of molecular motors trafficking subdiffusing cargos in viscoelastic cytosol by (i) including mechanochemical coupling between cyclic conformational fluctuations of the motor protein driven by the reaction of ATP hydrolysis and its translational motion within the simplest two-state model of hand-over-hand motion of kinesin, and also (ii) by taking into account the anharmonicity of the tether between the motor and cargo (its maximally possible extension length). It is shown that the major earlier results such as occurrence of normal versus anomalous transport depending on the amplitude of binding potential, cargo size and the motor turnover frequency not only survive in this more realistic model, but the results also look very similar for the correspondingly adjusted parameters. However, this more realistic model displays a substantially larger thermodynamic efficiency due to a bidirectional mechanochemical coupling. For realistic parameters, the maximal thermodynamic efficiency can be transiently about 50% as observed for kinesins, and even larger, surprisingly also in a novel strongly anomalous (sub)transport regime, where the motor enzymatic turnovers become also anomalously slow and cannot be characterized by a turnover rate. Here anomalously slow dynamics of the cargo enforces anomalously slow cyclic kinetics of the motor protein.

References in corpus (18)

• Brownian motors: noisy transport far from equilibrium
• Anomalous transport in the crowded world of biological cells
• In vivo anomalous diffusion and weak ergodicity breaking of lipid granules
• Biological measurement beyond the quantum limit
• Energy Transduction of Isothermal Ratchets: Generic Aspects and Specific Examples Close to and Far from Equilibrium
• Viscoelastic subdiffusion: from anomalous to normal
• Coexistence and efficiency of normal and anomalous transport by molecular motors in living cells
• Transition to superdiffusive behavior in intracellular actin-based transport mediated by molecular motors
• Molecular motors transporting cargos in viscoelastic cytosol: how to beat subdiffusion with a power stroke?
• Fractional Brownian motors and Stochastic Resonance
• Anomalous features of diffusion in corrugated potentials with spatial correlations: faster than normal, and other surprises
• Subdiffusive Brownian ratchets rocked by a periodic force
• Fractional time random walk subdiffusion and anomalous transport with finite mean residence times: faster, not slower
• Subdiffusive rocking ratchets in viscoelastic media: transport optimization and thermodynamic efficiency in overdamped regime
• Flashing subdiffusive ratchets in viscoelastic media
• Rocking Subdiffusive Ratchets: Origin, Optimization and Efficiency
• Force and Motion Generation of Molecular Motors: A Generic Description
• Is subdiffusional transport slower than normal?

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• Active and Passive Transport of Cargo in a Corrugated Channel: A Lattice Model Study
• Investigation of multiple-dynein transport of melanosomes by non-invasive force measurement using fluctuation unit $\chi$