Residence times of receptors in dendritic spines analyzed by simulations in empirical domains

Abstract

Analysis of high-density superresolution imaging of receptors reveal the organization of dendrites at the nano-scale resolution. We present here simulations in empirical live cell images, which allows converting local information extracted from short range trajectories into simulations of long range trajectories. Based on these empirical simulations, we compute the residence time of an AMPA receptor (AMPAR) in dendritic spines that accounts for receptors local interactions and geometrical organization. We report here that depending on the type of the spine, the residence time varies from one to five minutes. Moreover, we show that there exists transient organized structures, previously described as potential wells that can regulate the trafficking of AMPARs to dendritic spines.

arXiv comment19 pages

References in corpus (2)

• Mapping the energy and diffusion landscapes of membrane proteins at the cell surface using high-density single-molecule imaging and Bayesian inference: application to the multi-scale dynamics of glycine receptors in the neuronal membrane
• Potential wells for AMPA receptors organized in ring nanodomains

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