Coherent regulation in yeast cell cycle network
arXiv:1406.7441 · doi:10.1088/1478-3975/12/3/036002
Abstract
We define a measure of coherent activity for gene regulatory networks, a property that reflects the unity of purpose between the regulatory agents with a common target. We propose that such harmonious regulatory action is desirable under a demand for energy efficiency and may be selected for under evolutionary pressures. We consider two recent models of the cell-cycle regulatory network of the budding yeast, Saccharomyces cerevisiae, as a case study and calculate their degree of coherence. A comparison with random networks of similar size and composition reveals that the yeast's cell-cycle regulation is wired to yield and exceptionally high level of coherent regulatory activity. We also investigate the mean degree of coherence as a function of the network size, connectivity and the fraction of repressory/activatory interactions.
17 pages, 6 figures, 4 tables. Extensively revised and submitted for publication
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