Suppression and enhancement of transcriptional noise by DNA looping
arXiv:1406.2893 · doi:10.1103/PhysRevE.89.062703
Abstract
DNA looping has been observed to enhance and suppress transcriptional noise but it is uncertain which of these two opposite effects is to be expected for given conditions. Here, we derive analytical expressions for the main quantifiers of transcriptional noise in terms of the molecular parameters and elucidate the role of DNA looping. Our results rationalize paradoxical experimental observations and provide the first quantitative explanation of landmark individual-cell measurements at the single molecule level on the classical lac operon genetic system [Choi et al., Science 322, 442-446 (2008)].
arXiv comment13 pages, 6 figures, supplementary information
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