Chemical warfare and survival strategies in bacterial range expansions

Abstract

Dispersal of species is a fundamental ecological process in the evolution and maintenance of biodiversity. Limited control over ecological parameters has hindered progress in understanding of what enables species to colonise new area, as well as the importance of inter-species interactions. Such control is necessary to construct reliable mathematical models of ecosystems. In our work, we studied dispersal in the context of bacterial range expansions and identified the major determinants of species coexistence for a bacterial model system of three Escherichia coli strains (toxin producing, sensitive, and resistant). Genetic engineering allowed us to tune strain growth rates and to design different ecological scenarios (cyclic and hierarchical). We found that coexistence of all strains depended on three strongly interdependent factors: composition of inoculum, relative strain growth rates, and effective toxin range. Robust agreement between our experiments and a thoroughly calibrated computational model enabled us to extrapolate these intricate interdependencies in terms of phenomenological biodiversity laws. Our mathematical analysis also suggested that cyclic dominance between strains is not a prerequisite for coexistence in competitive range expansions. Instead, robust three-strain coexistence required a balance between growth rates and either a reduced initial ratio of the toxin-producing strain, or a sufficiently short toxin range.

31 pages, 5 figures

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Cited by in corpus (13)

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• The effect of habitats and fitness on species coexistence in systems with cyclic dominance
• Heterogeneous bacterial swarms with mixed lengths
• Influence of the neighborhood on cyclic models of biodiversity
• Stochasticity enhances the gaining of bet-hedging strategies in contact-process-like dynamics
• Specialization and Bet Hedging in Heterogeneous Populations
• Cooperation in Microbial Populations: Theory and Experimental Model Systems
• Demographic noise slows down cycles of dominance
• Snowdrift game induces pattern formation in systems of self-propelled particles