Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm

Abstract

We present a mathematical model which explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained using a model of synaptic metaplasticity, while the use-dependence (which is critically reliant on the presence of kinase in the experiment) is explained using a model of a stochastic and bistable biological switch.

12 pages, 7 figures, to appear in PLoS One (2013)

References in corpus (1)

• Power-law forgetting in synapses with metaplasticity

Cited by in corpus (2)

• Slow synaptic dynamics in a network: from exponential to power-law forgetting
• Storing and retrieving long-term memories: cooperation and competition in synaptic dynamics