Benchmarking GEANT4 nuclear models for hadron therapy with 95 MeV/nucleon carbon ions

Abstract

In carbon-therapy, the interaction of the incoming beam with human tissues may lead to the production of a large amount of nuclear fragments and secondary light particles. An accurate estimation of the biological dose deposited into the tumor and the surrounding healthy tissues thus requires sophisticated simulation tools based on nuclear reaction models. The validity of such models requires intensive comparisons with as many sets of experimental data as possible. Up to now, a rather limited set of double di erential carbon fragmentation cross sections have been measured in the energy range used in hadrontherapy (up to 400 MeV/A). However, new data have been recently obtained at intermediate energy (95 MeV/A). The aim of this work is to compare the reaction models embedded in the GEANT4 Monte Carlo toolkit with these new data. The strengths and weaknesses of each tested model, i.e. G4BinaryLightIonReaction, G4QMDReaction and INCL++, coupled to two di fferent de-excitation models, i.e. the generalized evaporation model and the Fermi break-up are discussed.

References in corpus (4)

• New potentialities of the Liège intranuclear cascade (INCL) model for reactions induced by nucleons and light charged particles
• Double di ffential fragmentation cross sections measurements of 95 MeV/u 12C on thin targets for hadrontherapy
• Measurements of total and partial charge-changing cross sections for 200-400 MeV/nucleon 12C in water and polycarbonate
• Comparison of two analysis methods for nuclear reaction measurements of 12C +12C interactions at 95 MeV/u for hadrontherapy

Cited by in corpus (7)

• Extension of the Liège Intranuclear-Cascade model to reactions induced by light nuclei
• Zero degree measurements of 12C fragmentation at 95 MeV/nucleon on thin targets
• Examination of cluster production in excited light systems at Fermi energies from new experimental data and comparison with transport model calculations
• A model for particle production in nuclear reactions at intermediate energies: application to C-C collisions at 95 MeV/nucleon
• Preliminary results in using Deep Learning to emulate BLOB, a nuclear interaction model
• Light fragments from (C + Be) interactions at 0.6 GeV/nucleon
• Study of Nucleon Charge-Exchange Processes at ${}^{12}$C Fragmentation with an Energy of 300 MeV/Nucleon