Revealing the missing heritability via cross-validated genome-wide association studies

Abstract

Presented here is a simple method for cross-validated genome-wide association studies (cvGWAS). Focusing on phenotype prediction, the method is able to reveal a significant amount of missing heritability by properly selecting a small number of loci with implicit predictive ability. The results provide new insights into the missing heritability problem and the underlying genetic architecture of complex traits.

7 pages main text, 2 figures, 2 supplementary tables, 49 supplementary figures