Bursts of Active Transport in Living Cells

Abstract

We scrutinize the temporally-resolved speed of active cargo transport in living cells, and show intermittent bursting motions. These nonlinear fluctuations follow a scaling law over several decades of time and space, the statistical regularities displaying a time-averaged shape that we interpret to reflect stress buildup followed by rapid release. The power law of scaling is the same as seen in driven jammed colloids, granular, and magnetic systems. The implied regulation of active transport with environmental obstruction extends the classical notion of molecular crowding.

References in corpus (5)

• Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors
• Active and Nonlinear Microrheology in Dense Colloidal Suspensions
• Creep motion of an intruder within a granular glass close to jamming
• Diagnosing Heterogeneous Dynamics in Single Molecule/Particle Trajectories with Multiscale Wavelets
• Negative differential mobility of weakly driven particles in models of glass formers

Cited by in corpus (10)

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• A Double-Spring Model for Nanoparticle Diffusion in a Polymer Network
• How we move is universal: scaling in the average shape of human activity
• Machine Learning Analysis of Anomalous Diffusion
• Navigation strategies of motor proteins on decorated tracks