Single-Base DNA Discrimination via Transverse Ionic Transport
arXiv:1307.0055 · doi:10.1088/0957-4484/24/41/415101
Abstract
We suggest to discriminate single DNA bases via transverse ionic transport, namely by detecting the ionic current that flows in a channel while a single-stranded DNA is driven through an intersecting nanochannel. Our all-atom molecular dynamics simulations indeed show that the ionic currents of the four bases are statistically distinct, thus offering another possible approach to sequence DNA.
5 pages, 3 figures