paper

Dynamics of Self-Assembly of Model Viral Capsids in the Presence of a Fluctuating Membrane

arXiv:1306.1682 · doi:10.1021/jp4037099

Abstract

A coarse-grained computational model is used to investigate the effect of a fluctuating fluid membrane on the dynamics of patchy-particle assembly into virus capsid-like cores. Results from simulations for a broad range of parameters are presented, showing the effect of varying interaction strength, membrane stiffness and membrane viscosity. Furthermore, the effect of hydrodynamic interactions is investigated. Attraction to a membrane may promote assembly, including for sub-unit interaction strengths for which it does not occur in the bulk, and may also decrease single-core assembly time. The membrane budding rate is strongly increased by hydrodynamic interactions. The membrane deformation rate is important in determining the finite-time yield. Higher rates may decrease the entropic penalty for assembly and help guide sub-units towards each other but may also block partial cores from being completed. For increasing sub-unit interaction strength, three regimes with different effects of the membrane are identified.

31 pages, 12 figures, to be published in The Journal of Physical Chemistry B

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