Molecular Dynamics Studies on 3D Structures of the Hydrophobic Region PrP(109-136)
arXiv:1301.0117 · doi:10.1093/abbs/gmt031
Abstract
Prion diseases caused by the conversion from a soluble normal cellular prion protein into insoluble abnormally folded infectious prions, are invariably fatal and highly infectious degenerative diseases that affect a wide variety of mammalian species. The palindrome and the Glycine-rich conserved segment in the hydrophobic region 109-136 control the conversion from normal prion protein to form into diseased prions. This paper gives detailed reviews on the 109-136 region and presents the studies of its 3D structures and structural dynamics.
This paper was accepted on 18-02-2013 by the journal Acta Biochimica et Biophysica Sinica, in press in Vol 45 No 4, Apr 2013