Flexible composition and execution of high performance, high fidelity multiscale biomedical simulations

Abstract

Multiscale simulations are essential in the biomedical domain to accurately model human physiology. We present a modular approach for designing, constructing and executing multiscale simulations on a wide range of resources, from desktops to petascale supercomputers, including combinations of these. Our work features two multiscale applications, in-stent restenosis and cerebrovascular bloodflow, which combine multiple existing single-scale applications to create a multiscale simulation. These applications can be efficiently coupled, deployed and executed on computers up to the largest (peta) scale, incurring a coupling overhead of 1 to 10% of the total execution time.

accepted by Interface Focus. 17 pages, 2 figures, 4 tables

References in corpus (3)

• A Light-Weight Communication Library for Distributed Computing
• High Performance Gravitational N-body Simulations on a Planet-wide Distributed Supercomputer
• Coalesced communication: a design pattern for complex parallel scientific software

Cited by in corpus (1)

• An automated multiscale ensemble simulation approach for vascular blood flow