The layer impact of DNA translocation through graphene nanopores

Abstract

Graphene nanopore based sensor devices are exhibiting the great potential for the detection of DNA. To understand the fundamental aspects of DNA translocating through a graphene nanopore, in this work, molecular dynamics (MD) simulations and potential of mean force (PMF) calculations were carried out to investigate the layer impact of small graphene nanopore (2 nm-3 nm) to DNA translocation. It was observed that the ionic conductance was sensitive to graphene layer of open-nanopores, the probability for DNA translocation through graphene nanopore was related with the thickness of graphene nanopores. MD simulations showed that DNA translocation time was most sensitive to the thickness of graphene nanopore for a 2.4 nm aperture, and the observed free energy barrier of PMFs and the profile change revealed the increased retardation of DNA translocation through bilayer graphene nanopore as compared to monolayer graphene nanopore.

arXiv comment22 pages, 4 figures

References in corpus (7)

• Graphene: Status and Prospects
• Graphene: A sub-nanometer trans-electrode membrane
• DNA Translocation through Graphene Nanopores
• Electron beam nanosculpting of suspended graphene sheets
• Liquid-vapor oscillations of water in hydrophobic nanopores
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• The Interfacial-Organized Monolayer Water Hindering the Aggregation of Nanographene: Both in Stacking and Sliding Assembly Pathways
• Interlayer Water Regulates the Bio-nano Interface of a \b{eta}-sheet Protein stacking on Graphene
• How effective is graphene nanopore geometry on DNA sequencing?
• Direct and Scalable Chemical Vapor Deposition of Ultrathin Low-Noise MoS2 Membranes on Apertures
• Locking ssDNA in a Graphene-Terraces Nanopore and Steering Its Step-by-Step Transportation via Electric Trigger