Semiparametric Relative-risk Regression for Infectious Disease Data

Abstract

This paper introduces semiparametric relative-risk regression models for infectious disease data based on contact intervals, where the contact interval from person i to person j is the time between the onset of infectiousness in i and infectious contact from i to j. The hazard of infectious contact from i to j is λ_0(τ)r(β_0^T X_{ij}), where λ_0(τ) is an unspecified baseline hazard function, r is a relative risk function, β_0 is an unknown covariate vector, and X_{ij} is a covariate vector. When who-infects-whom is observed, the Cox partial likelihood is a profile likelihood for βmaximized over all possible λ_0(τ). When who-infects-whom is not observed, we use an EM algorithm to maximize the profile likelihood for βintegrated over all possible combinations of who-infected-whom. This extends the most important class of regression models in survival analysis to infectious disease epidemiology.

38 pages, 5 figures

References in corpus (3)

• Generation interval contraction and epidemic data analysis
• Contact intervals, survival analysis of epidemic data, and estimation of R_0
• Nonparametric survival analysis of epidemic data

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