Sources of stochasticity in constitutive and autoregulated gene expression

Abstract

Gene expression is inherently noisy as many steps in the read-out of the genetic information are stochastic. To disentangle the effect of different sources of stochasticity in such systems, we consider various models that describe some processes as stochastic and others as deterministic. We review earlier results for unregulated (constitutive) gene expression and present new results for a gene controlled by negative autoregulation with cell growth modeled by linear volume growth.

arXiv comment7 pages, 6 figures, physica scripta in press (2012)

References in corpus (3)

• Noise-based switches and amplifiers for gene expression
• Deterministic characterization of stochastic genetic circuits
• Deterministic and stochastic descriptions of gene expression dynamics