Lévy Noise Induced Switch in the Gene Transcriptional Regulatory System

Abstract

Gene transcriptional regulatory is an inherently noisy process. In this paper, the study of fluctuations in a gene transcriptional regulatory system is extended to the case of Lévy noise, a kind of non-Gaussian noises which can describe unpredictable jump changes of the random environment. The stationary probability density is given to explore the key roles of Lévy noise in the gene regulatory networks. The results demonstrate that the parameters of Lévy noise, including noise intensity, stability index and skewness parameter can induce switches between distinct gene-expression states. A further concern is the switching time (from the high concentration state to the low concentration one or from the low concentration state to the high concentration one), which is a random variable and often referred to as the mean first passage time. The effects of Lévy noise in expression time and degradation time is studied by computing the mean first passage time in two directions and a number of different peculiarities of non-Gaussian Lévy noise compared with Gaussian noise are observed.

19 pages, 17 figures

References in corpus (2)

• Determining the stability of genetic switches: explicitly accounting for mRNA noise
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