The capacitance and electromechanical coupling of lipid membranes close to transitions. The effect of electrostriction

Abstract

Biomembranes are thin capacitors with the unique feature of displaying phase transitions in a physiologically relevant regime. We investigate the voltage and lateral pressure dependence of their capacitance close to their chain melting transition. Since the gel and the fluid membrane have different area and thickness, the capacitance of the two membrane phases is different. In the presence of external fields, charges exert forces that can influence the state of the membrane, thereby influencing the transition temperature. This phenomenon is called electrostriction. We show that this effect allows us to introduce a capacitive susceptibility that assumes a maximum in the melting transition with an associated excess charge. As a consequence, there exist voltage regimes where a small change in voltage can lead to a large uptake of charge and a large capacitive current. Furthermore, we consider electromechanical behavior such as pressure-induced changes in capacitance, and the application of such concepts in biology.

arXiv comment5 figures

References in corpus (7)

• The temperature dependence of lipid membrane permeability, its quantized nature, and the influence of anesthetics
• The thermodynamics of general anesthesia
• Lipid Ion Channels
• On the action potential as a propagating density pulse and the role of anesthetics
• The influence of anesthetics, neurotransmitters and antibiotics on the relaxation processes in lipid membranes
• Periodic solutions and refractory periods in the soliton theory for nerves and the locust femoral nerve
• Comparing ion conductance recordings of synthetic lipid bilayers with cell membranes containing TRP channels

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