Single-molecule pulling: phenomenology and interpretation
arXiv:1205.5068 · doi:10.1002/9781118482568.ch14
Abstract
Single-molecule pulling techniques have emerged as versatile tools for probing the noncovalent forces holding together the secondary and tertiary structure of macromolecules. They also constitute a way to study at the single-molecule level processes that are familiar from our macroscopic thermodynamic experience. In this Chapter, we summarize the essential phenomenology that is typically observed during single-molecule pulling, provide a general statistical mechanical framework for the interpretation of the equilibrium force spectroscopy and illustrate how to simulate single-molecule pulling experiments using molecular dynamics.
arXiv admin note: text overlap with arXiv:0908.2208
References in corpus (5)
- Rare events and the convergence of exponentially averaged work values
- Single-molecule derivation of salt dependent base-pair free energies in DNA
- Experimental Free Energy Surface Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality
- Optimized free energies from bidirectional single-molecule force spectroscopy
- Reconstructing the free energy landscape of a polyprotein by single-molecule experiments